Interplay of biopharmaceutics, biopharmaceutics drug disposition and salivary excretion classification systems

BIOPHARMACEUTICS DRUG DISPOSITION CLASSIFICATION SYSTEM: AN EXTENSION OF BIOPHARMACEUTICS CLASSIFICATION SYSTEM Kataria

The Biopharmaceutics Classification System (BCS) was developed for prediction of in vivo pharmacokinetic performance of drug products from measurements of permeability and solubility. If the permeability criteria changed with metabolism criteria than it may be useful in predicting overall drug disposition, including routes of drug elimination and the effects of efflux and absorptive transporter...

Biopharmaceutics and Pharmacokinetics

International Journal of Biopharmaceutics

The present study investigates the effect of Withania somnifera (WS), a well-known adaptogenic agent in Indian system of Medicine, on acute cerebral reperfusion and long-term cerebral hypoperfusion in rats. Acute ischemiareperfusion (30 min occlusion of bilateral common carotid arteries followed by 45 min. reperfusion) and Long-term cerebral hypoperfusion (for 15 days) in C.F. strain rats were ...

Biopharmaceutics Classification System: A Regulatory Approach

The Biopharmaceutics Classification System (BCS) is the result of continuous efforts in mathematical analysis for the elucidation of the kinetics and dynamics of the drug process in the gastrointestinal tract (GIT) for NDA (New Drug Application) and ANDA (Abbreviated New Drug Application) filings and biowaivers. This step reduces timelines in the new drug development process, both directly and ...

Clinical Pharmacology and Biopharmaceutics Review

Tiotropium bromide monohydrate is an anticholinergic drug with specificity for muscarinic receptors, proposed to be used for the long-term, once-daily, maintenance treatment of bronchospasm and dyspnea associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. The proposed dosage of tiotropium is inhalation of the contents of one capsule (18 μg of ...